Chia‐Yi Lee

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency

This study uses reverse genetics in humanized mice to show that DPP9 deficiency causes CARD8-mediated pyroptosis in human hematopoietic stem and progenitor cells, leading to pancytopenia.

Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states

The paper identifies glial cell-specific regulatory elements and genetic risk modifiers in tau-related dementias using single-nucleus epigenomic profiling.

hiPSC-derived astrocytes from individuals with schizophrenia induce a dystrophic phenotype in microglial-like cells

The paper shows that SCZ astrocytes, when stimulated, induce a dystrophic phenotype in microglial-like cells through altered cytokine profiles and impaired phagocytosis.

Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia

This study uses single-nucleus RNA sequencing to analyze periventricular white matter in vascular dementia, identifying increased heat shock protein responses as a conserved feature across cell types.