Eric Van Otterloo

This study shows that loss of PRMT5 in skin leads to defective stratification and an atypical keratinocyte population with senescence-like features.

The paper identifies rare mutations in SIX1, PDGFRA, and KDR/VEGFR2 associated with OAVS phenotypes through whole genome sequencing and statistical analysis of a family.

The paper identifies key transcription factors in Sox2+ dental epithelial stem cells from embryonic and postnatal stages using single-cell RNA-seq and ATAC-seq.

The paper shows that TFAP2 paralogs regulate midfacial development via the ALX genetic pathway in mice and zebrafish.

The paper identifies transcription factors and regulatory networks involved in dental lamina specification during tooth initiation using single-cell Multiome-seq and RNA-seq.

The paper shows TFAP2 paralogs enhance MITF's ability to activate pigmentation genes but independently repress cell adhesion genes, affecting melanocyte and melanoma cell behavior.

This study shows that AP-2α and AP-2β regulate chromatin and gene expression in the craniofacial surface ectoderm, affecting facial development and WNT signaling in mice.

This study shows that Tfap2a and Tfap2b have tissue-specific roles in tooth development, with epithelial expression critical for incisor morphology and mesenchymal expression having little effect.

The paper identifies differences in alternative polyadenylation (APA) between mouse cerebellar neuron types and shows how APA affects gene regulation and function.