Author

Ramile Dilshat

University of IcelandORCID 0000-0002-2126-2902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:ATAC-seq· 2 Assay:ChIP-seq· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1

Frequent Co-Authors

Eirı́kur Steingrı́mssoniD· 3 shared Adrián López García de LomanaiD· 1 shared Alisa M. GoldsteiniD· 1 shared Annika HelversoniD· 1 shared Berglind Osk EinarsdottiriD· 1 shared C Cao· 1 shared Christopher M. Franke· 1 shared Colin KennyiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMolecular Biology

Eirı́kur Steingrı́mssonORCID

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Author profile →

4 papers

Recent·Most cited

MITF maintains genome stability in non-melanocytic cell lineages and suppresses Hippo pathway signaling

Drífa Hrund Guðmundsdóttir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snævar Sigurðsson, Linda Vidarsdóttir, Ramile Dilshat, Erla Sveinbjornsdottir, Snædís Ragnarsdóttir, Daniel Heidar Magnusson, Maria Rose Bustos, Eirı́kur Steingrı́msson, Þorkell Guðjόnsson, Stefán Sigurðsson

This study shows MITF maintains genome stability in non-melanocytic cells by suppressing Hippo pathway signaling through LATS2 and ATR.

bioRxiv · Jun 9, 2025 · PreprintMolecular Biology

In vivo silencing of regulatory elements using a single AAV-CRISPRi vector

Patrick Laurette, C Cao, Deepak Prabhu Ramanujam, Martin Schwaderer, T. Lueneburg, S Kuss, L. Weiss, Ramile Dilshat, Eileen E. M. Furlong, Flávia Rezende, Stefan Hanns Engelhardt, Ralf Gilsbach

This paper develops an AAV-based CRISPRi system to silence gene expression in cardiac myocytes, showing dose-dependent reduction of Nppa expression in vitro and in vivo.

bioRxiv · Nov 5, 2023 · PreprintGenomics

TFAP2 paralogs facilitate chromatin access for MITF at pigmentation genes but inhibit expression of cell-cell adhesion genes independently of MITF

Colin Kenny, Ramile Dilshat, Hannah Seberg, Eric Van Otterloo, Gregory Bonde, Annika Helverson, Christopher M. Franke, Eirı́kur Steingrı́msson, Robert A. Cornell

The paper shows TFAP2 paralogs enhance MITF's ability to activate pigmentation genes but independently repress cell adhesion genes, affecting melanocyte and melanoma cell behavior.

PLoS Genetics · May 17, 2022Peer-reviewedDevelopmental Biology

Cell type-specific meQTL extends melanoma GWAS annotation beyond eQTL and informs melanocyte gene regulatory mechanisms

Tongwu Zhang, Jiyeon Choi, Ramile Dilshat, Berglind Osk Einarsdottir, Michael A. Kovacs, Mai Xu, Michael Malasky, Salma Chowdhury, Kristine M. Jones, David Timothy Bishop, Alisa M. Goldstein, Mark Martin Iles, Maria Teresa Landi, Matthew H. Law, Jianxin Shi, , Kevin M. Brown

The paper identifies cell-type-specific meQTLs in melanocytes and melanomas, enhancing GWAS annotation and revealing regulatory mechanisms involving IRF4.

The American Journal of Human Genetics · Jul 21, 2021Peer-reviewedGenetics