Author

Iván Martínez-Valbuena

University of TorontoORCID 0000-0001-6463-6321Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

Gábor Géza KovácsiD· 4 shared Anthony Edward LangiD· 3 shared Ain KimiD· 2 shared Ekaterina A. RogaevaiD· 2 shared Joel C. WattsiD· 2 shared Naomi P. VisanjiiD· 2 shared Shelley L. ForrestiD· 2 shared Ali Mohammadi Karakani· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersNeuroscience

Gábor Géza KovácsORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 7, 2026

Differently sized soluble α-synuclein species from multiple system atrophy and Lewy body disease brains display different seeding propensities

Silvia Zampar, Y. Mei, Filsy Samuel…·Martin Ingelsson

This study compares soluble α-synuclein species from MSA and LBD brains, finding differences in their seeding activity and size distribution.

DOI 10.64898/2026.08.03.742519

humanproteomics

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PathologyCommunications BiologyPeer-reviewedJun 16, 2025

Lewy-MSA hybrid fold drives distinct neuronal a-synuclein pathology

Masahiro Enomoto, Iván Martínez-Valbuena, Shelley L. Forrest…·Gábor Géza Kovács

The paper identifies a Lewy-MSA hybrid fold of α-synuclein in atypical MSA, linking distinct filament structures to neuronal versus oligodendroglial pathologies.

14 citationstop 2%

humanproteomics

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NeurosciencebioRxivPreprintSep 28, 2023

4R-Tau seeding activity unravels molecular subtypes in patients with Progressive Supranuclear Palsy

Iván Martínez-Valbuena, Seojin Lee, Enrique Santamaría…·Gábor Géza Kovács

The paper investigates molecular subtypes in PSP by analyzing tau seeding activity and identifies immune-related pathways associated with disease progression.

11 citations

humanproteomics

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NeuroscienceTranslational NeurodegenerationPeer-reviewedFeb 6, 2022

A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy

Iván Martínez-Valbuena, Naomi P. Visanji, Ain Kim…·Gábor Géza Kovács

This study introduces a modified Real-Time Quaking-induced Conversion assay to assess alpha-synuclein seeding activity in multiple system atrophy, revealing heterogeneity in seeding behavior across brain regions.

103 citationstop 1%

humanprotein structure

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