Physiological (TCR-like) regulated lentiviral vectors for the generation of improved CAR-T cells
María Tristán‐Manzano, Noelia Maldonado‐Pérez, Pedro Justicia-Lirio, Pilar Muñoz, Marina Cortijo-Gutierréz, Kristina Pavlovic, Rosario Jimenez‐Moreno, Sonia Nogueras, Maria Dolores Carmona-Luque, Sabina Sánchez-Hernández, Araceli Aguilar-González, María Castellà, Manel Juan, Concepción Marañón, Juan Antonio Marchal, , Francisco Martı́n
This paper develops lentiviral vectors with TCR-like expression patterns to generate CAR-T cells with reduced tonic signaling and improved therapeutic profiles.
Molecular Therapy — Oncolytics · May 17, 2022Peer-reviewedGenetic & Genomic Medicine