Author

Francisco Martı́n

Universidad de GranadaORCID 0000-0003-1961-8612Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Araceli Aguilar-GonzáleziD· 2 shared Concha HerreraiD· 2 shared Francisco J. Molina-EstéveziD· 2 shared Juan Antonio MarchaliD· 2 shared Kristina PavloviciD· 2 shared María Tristán‐ManzanoiD· 2 shared Marina Cortijo-GutierréziD· 2 shared Noelia Maldonado‐PéreziD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Araceli Aguilar-GonzálezORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicineNucleic Acids ResearchPeer-reviewedFeb 24, 2026

A Novel Dual-Guide CRISPR-Cas13 Strategy Improves Specificity for Single-Nucleotide Variant Detection

Araceli Aguilar-González, Ismael Martos-Jamai, Iris Ramos-Hernández…·Francisco Martı́n

This paper introduces a dual-guide CRISPR-Cas13 system that improves specificity for single-nucleotide variant detection without reducing sensitivity.

8 citationstop 1%

CRISPR screenexperimental assay

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ImmunologyMolecular Therapy — Nucleic AcidsPeer-reviewedAug 15, 2024

First-in-class Transactivator-Free, Doxycycline-inducible IL-18-engineered CAR-T cells for relapsed/refractory B-cell lymphomas

Pedro Justicia-Lirio, María Tristán‐Manzano, Noelia Maldonado‐Pérez…·Francisco Martín

This paper develops doxycycline-inducible IL-18 CAR-T cells (iTRUCK19.18) that enhance antitumor activity while controlling IL-18 release through dual mechanisms.

7 citations

humanCITE-seq

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Genetic & Genomic MedicineMolecular Therapy — OncolyticsPeer-reviewedMay 17, 2022

Physiological (TCR-like) regulated lentiviral vectors for the generation of improved CAR-T cells

María Tristán‐Manzano, Noelia Maldonado‐Pérez, Pedro Justicia-Lirio…·Francisco Martı́n

This paper develops lentiviral vectors with TCR-like expression patterns to generate CAR-T cells with reduced tonic signaling and improved therapeutic profiles.

25 citations

humanexperimental assay

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