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Assessing the Molecular Validity of Spontaneous Lupus Mouse Models and Its Implication for Human Studies

This study evaluates molecular pathways in four spontaneous lupus mouse models and compares them to human SLE to assess translational relevance and guide future research.

Systemic autoimmune disease patients' blood immunome reveals specificities and commonalities among different diagnostic entities

The paper uses immunophenotyping to identify patient subgroups in systemic autoimmune diseases, revealing shared immunophenotypes and cytokine signatures across different diagnoses.

The Lupus Epigenome Relates to Genetics, Transcription and Serological Profiles with Dependency on Molecular Subtypes and Informs Drug Discovery

This study identifies epigenetic differences in SLE linked to genetics, transcription, and serology, revealing novel drug targets and pathways.

Physiological (TCR-like) regulated lentiviral vectors for the generation of improved CAR-T cells

This paper develops lentiviral vectors with TCR-like expression patterns to generate CAR-T cells with reduced tonic signaling and improved therapeutic profiles.

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

The paper identifies four molecular clusters in systemic autoimmune diseases using transcriptome and methylome data, showing three stable aberrant patterns and one non-specific cluster.

An integrative multi-omics approach in Sjogrens Syndrome identifies novel genetic drivers with regulatory function and disease-specificity

This study identifies novel genetic drivers in Sjogrens Syndrome through an integrative multi-omics approach, revealing epigenetic signatures and regulatory variants associated with the disease.