Author

Joseph H. Lobel

University of California, BerkeleyORCID 0000-0001-5986-7280Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Nicholas T. IngoliaiD· 3 shared Anna J. RogersiD· 1 shared Anna V. FreitasiD· 1 shared Elijah F. Lyons· 1 shared Liana F. LareauiD· 1 shared Lou DevanneauxiD· 1 shared Maria V. McSharryiD· 1 shared Ryan Yue MulleriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Nicholas T. IngoliaORCID

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3 papers

Recent·Most cited

Translation elongation as a rate limiting step of protein production

Elijah F. Lyons, Lou Devanneaux, Ryan Yue Muller, Anna V. Freitas, Zuriah A. Meacham, Maria V. McSharry, Van N. Trinh, Anna J. Rogers, Joseph H. Lobel, Nicholas T. Ingolia, Liana F. Lareau

The paper shows that slow translation elongation reduces protein output per mRNA, independent of mRNA stability, and demonstrates a dynamic balance between initiation and elongation rates.

Cell Systems · Feb 1, 2026Peer-reviewedMolecular Biology

Precise measurement of molecular phenotypes with barcode-based CRISPRi systems

Joseph H. Lobel, Nicholas T. Ingolia

The paper introduces CiBER-seq, a CRISPRi platform that improves the sensitivity and scope of genome-wide screens by normalizing expression reporters against control promoters, and validates its ability to capture post-transcriptional and post-translational regulation.

Genome biology · May 25, 2025Peer-reviewedGenomics

Defining the mechanisms and properties of post-transcriptional regulatory disordered regions by high-throughput functional profiling

Joseph H. Lobel, Nicholas T. Ingolia

The paper identifies regulatory sequences in disordered regions of RNA binding proteins and shows how they modulate mRNA decay through interactions with core machinery.

Nature · Apr 23, 2025Peer-reviewedGenomics