Translation elongation as a rate limiting step of protein production
Elijah F. Lyons, Lou Devanneaux, Ryan Yue Muller, Anna V. Freitas, Zuriah A. Meacham, Maria V. McSharry, Van N. Trinh, Anna J. Rogers, Joseph H. Lobel, Nicholas T. Ingolia, Liana F. Lareau
The paper shows that slow translation elongation reduces protein output per mRNA, independent of mRNA stability, and demonstrates a dynamic balance between initiation and elongation rates.
Cell Systems · Feb 1, 2026Peer-reviewedMolecular Biology