Author

Christa Kietz

University of HelsinkiORCID 0000-0001-6000-9814Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Janne PurhoneniD· 3 shared Jukka KallijärviiD· 3 shared Rishi BanerjeeiD· 3 shared Vineta FellmaniD· 3 shared Divya UpadhyayiD· 2 shared Anni I. NiemineniD· 1 shared Maaria KankareiD· 1 shared Massimiliano GaetaniiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersPhysiology

Janne PurhonenORCID

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3 papers

Recent·Most cited

PhysiologyMolecular TherapyPeer-reviewedApr 25, 2026

Hepatic gene replacement restores energy metabolism and doubles the survival in mouse model of GRACILE syndrome, a neonatal mitochondrial disease

Rishi Banerjee, Janne Purhonen, Nasrin Sultana…·Jukka Kallijärvi

This study uses gene replacement in a mouse model of GRACILE syndrome to show improved energy metabolism and doubled survival through liver-specific correction of a mitochondrial complex III deficiency.

DOI 10.1016/j.ymthe.2026.04.044

mouseATAC-seq

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PhysiologybioRxivPreprintJul 8, 2025

Evolutionarily conserved temperature dependency leads to loss of protein O-GlcNAc in mammalian hypothermia

Divya Upadhyay, Christa Kietz, Nasrin Sultana…·Jukka Kallijärvi

This study identifies temperature as an evolutionarily conserved regulator of O-GlcNAcylation, showing that hypothermia reduces O-GlcNAc levels across species.

DOI 10.1101/2025.07.08.660373

mouseDrosophila

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PhysiologybioRxivPreprintSep 23, 2024

Hepatic mitochondrial respiration is crucial for euthermia in complex III-deficient mice with impaired brown adipose tissue thermogenesis

Rishi Banerjee, Divya Upadhyay, Tomáš Zárybnický…·Jukka Kallijärvi

This study shows that restoring mitochondrial complex III function in the liver of CIII-deficient mice prevents hypothermia and improves survival by enabling normal thermoregulation.

1 citation

mouseexperimental assay

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