Tomáš Zárybnický

Human models of GLE1 associated LCCS1 reveal neural crest deficiency and multisystem developmental failure accompanied by altered RNA metabolism

This study uses human stem cells and tissues to investigate LCCS1, revealing impaired RNA metabolism and developmental defects in neural crest and neuromuscular systems.

GLE1 dysfunction compromises cellular homeostasis, spatial organization, and peripheral axon branching

This study investigates the role of GLE1 in cellular homeostasis and development, showing that its dysfunction leads to embryonic lethality and mid-adulthood death in mice, with defects in neural crest-derived tissues and stress responses.

Hepatic mitochondrial respiration is crucial for euthermia in complex III-deficient mice with impaired brown adipose tissue thermogenesis

This study shows that restoring mitochondrial complex III function in the liver of CIII-deficient mice prevents hypothermia and improves survival by enabling normal thermoregulation.

Biomechanical regulation of cell shapes promotes branching morphogenesis of the ureteric bud epithelium

This study investigates how biomechanical regulation of cell shapes influences branching morphogenesis in the ureteric bud epithelium, identifying key cellular mechanics involved in branch formation.