A Drosophila genetic screen identifies glial adenosine metabolism genes as therapeutic targets for alpha-synucleinopathies by improving locomotion and reducing neurodegeneration.

2 citations

Drosophilaexperimental assay

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Molecular BiologyFrontiers in Aging NeurosciencePeer-reviewedJan 27, 2021

FOXO regulates neuromuscular junction homeostasis during Drosophila aging

Allison Birnbaum, Maggie Sodders, Mark J Bouska…·Hua Bai

This study shows FOXO maintains neuromuscular junction integrity during aging in Drosophila by repressing MAPK signaling.

18 citations

Drosophilaexperimental assay

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GeneticsG3 Genes Genomes GeneticsPeer-reviewedFeb 13, 2020

Reduced function of the glutathione S-transferase S1 suppresses behavioral hyperexcitability in Drosophila expressing a mutant voltage-gated sodium channel

Hung-Lin Chen, Junko Kasuya, Patrick Lansdon…·Toshihiro Kitamoto

The paper identifies GstS1 as a modifier of Nav-channel mutant phenotypes in Drosophila, showing reduced GstS1 function suppresses hyperexcitability in paraShu mutants.

6 citations

Drosophilaexperimental assay

𝕏 PostBluesky