Garrett A. Kaas

HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization

This study investigates the role of the HEXIM1/P-TEFb complex in regulating RNA polymerase II pause release and immediate early gene induction in neurons during depolarization.

Oncometabolite-driven enhancer hypermethylation promotes a hyporesponsive microglial state in IDH-mutant gliomas

This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.

Tet1 isoforms differentially regulate gene expression, synaptic transmission and memory in the mammalian brain.

This study identifies two Tet1 isoforms with distinct roles in gene expression, synaptic transmission, and memory in the mammalian brain.

Reduced function of the glutathione S-transferase S1 suppresses behavioral hyperexcitability in Drosophila expressing a mutant voltage-gated sodium channel

The paper identifies GstS1 as a modifier of Nav-channel mutant phenotypes in Drosophila, showing reduced GstS1 function suppresses hyperexcitability in paraShu mutants.

Tet2 negatively regulates memory fidelity

This study shows that Tet2 negatively regulates long-term memory fidelity by modulating DNA methylation in hippocampal neurons.