Rafael Roesler

This study identifies CRTC1 as a marker of transcriptional heterogeneity in Group 3 β medulloblastoma, linking its expression to survival and tumor microenvironment features.

This study identifies high PSEN1 expression as a favorable-prognosis state in SHH medulloblastoma, associated with a distinct transcriptional program.

The paper identifies four serotonin receptor genes linked to favorable clinical and molecular features in IDH-mutant lower-grade gliomas, suggesting a neuronal/synaptic differentiation state.

The paper examines the expression of GRIA genes in medulloblastoma subgroups and finds subgroup-specific associations with patient survival.

This study identifies DLG2-DLG4 expression as linked to improved survival and a synaptic gene signature in lower-grade gliomas.

The paper shows that K252a treatment delays Ewing sarcoma tumor growth and reduces Trk, PI3K, and IGF1R expression and activity, with combined treatment more effective than single agents.

The paper examines TWIST1 expression in medulloblastoma subgroups, finding opposite associations with patient survival in SHH and Group 4 tumors.

This study shows that valproic acid reduces medulloblastoma cell viability and affects stemness, differentiation, and gene expression through histone acetylation changes.