Caroline Brunetto de Farias

The neuronal plasticity gene CRTC1 links survival with mitochondrial programs and tumor microenvironment features in Group 3 β medulloblastoma

This study identifies CRTC1 as a marker of transcriptional heterogeneity in Group 3 β medulloblastoma, linking its expression to survival and tumor microenvironment features.

PSEN1 Expression Identifies a Developmentally Distinct Favorable-Prognosis State in SHH α Medulloblastoma

This study identifies high PSEN1 expression as a favorable-prognosis state in SHH medulloblastoma, associated with a distinct transcriptional program.

Subgroup-Specific Associations of GRIA Genes Encoding AMPA Glutamate Receptor Subunits with Patient Survival in Medulloblastoma

The paper examines the expression of GRIA genes in medulloblastoma subgroups and finds subgroup-specific associations with patient survival.

Delayed growth of Ewing sarcoma tumors associated with reduced expression and activity of Trk receptors, PI3K, and IGF1R

The paper shows that K252a treatment delays Ewing sarcoma tumor growth and reduces Trk, PI3K, and IGF1R expression and activity, with combined treatment more effective than single agents.

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres

This study shows that valproic acid reduces medulloblastoma cell viability and affects stemness, differentiation, and gene expression through histone acetylation changes.