Emily F. Watts

LRP2 is a proteogenomics pipeline that integrates long-read RNA sequencing and mass spectrometry to detect novel protein isoforms and improve their translation inference.

The paper examines how the loss of a color morph in woodland salamanders affects asymmetric character release and evolutionary rates between morphs.

This study evaluates the Platinum sequencer's ability to detect proteoform-informative peptides, distinguishing TPM1/TPM2 paralogs, spliceforms, and PTMs.

Biosurfer identifies sources of protein isoform diversity by analyzing long-read RNA-seq data, revealing common mechanisms like alternative transcription start sites and 'ragged codons'.

The paper introduces LRP-IS-PRM, a method using long-read RNAseq to inform targeted proteomics with IS-PRM, identifying five new protein isoforms in human stem cells.