Aidan M. Fenix

Nascent transcript O-MAP reveals the molecular architecture of an RBM20-regulated single-locus subnuclear compartment organized around the TTN RNA

The paper uses O-MAP to study a cardiac-specific RNA factory around TTN RNA, revealing its chromatin interactions, RNA composition, and role of RBM20 in gene regulation.

IS-PRM-based peptide targeting informed by long-read sequencing for alternative proteome detection

The paper introduces LRP-IS-PRM, a method using long-read RNAseq to inform targeted proteomics with IS-PRM, identifying five new protein isoforms in human stem cells.

CRaTER enrichment for on-target gene-editing enables generation of variant libraries in hiPSCs

CRaTER enriches for on-target gene-edited cells in hiPSCs, enabling efficient generation of variant libraries for studying cardiomyopathy-associated mutations.