Author

Stephanie E. Leighton

Western UniversityORCID 0009-0004-7706-3496Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Brooke L. O’DonnelliD· 3 shared Silvia PeñuelaiD· 3 shared Brant E. IsaksoniD· 2 shared Dan StefaniD· 2 shared Danielle E. JohnstoniD· 2 shared John Andrew RonaldiD· 2 shared John Joseph KellyiD· 2 shared Matthew S. HuveriD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCell Biology

Brooke L. O’DonnellORCID

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3 papers

Recent·Most cited

Pannexin 1 Ablation Disrupts Cell Cycle Progression and Compromises the Structure of Melanoma Tumours

Stephanie E. Leighton, Danielle E. Johnston, Kevin Barr, Brooke L. O’Donnell, Wyatt J. Schug, Matthew S. Huver, Dan Stefan, Christopher A. Bonham, John Joseph Kelly, Ying Xia, Brant E. Isakson, John Andrew Ronald, Dale W. Laird, Silvia Peñuela

This study shows that PANX1 ablation disrupts cell cycle progression and tumor structure in melanoma, suggesting it as a therapeutic target.

bioRxiv · Oct 9, 2026 · PreprintCancer Biology

Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma

Samar Sayedyahossein, Kenneth Huang, Christopher Zhang, Mehdi Karimi, Mehrnoosh Bahmani, Brooke L. O’Donnell, Brent Wakefield, Zhigang Li, Danielle E. Johnston, Stephanie E. Leighton, Matthew S. Huver, Lina Dagnino, David B. Sacks, Silvia Peñuela

This study investigates the interaction between PANX1 and the Hippo pathway in melanoma, showing PANX1 modulates YAP levels and identifies potential therapeutic targets.

FEBS Journal · Jan 9, 2025Peer-reviewedCell Biology

Novel carboxy-terminal Pannexin 1 isoform is expressed in mouse melanoma cells and interacts with the full-length protein

Brooke L. O’Donnell, Dan Stefan, Yu‐Hsin Chiu, Michael J. Zeitz, Stephanie E. Leighton, Laura A. Orofiamma, Danielle Johnston, Justin Tang, Carlijn Van Kessel, Kevin Barr, Laszlo Gyenis, Taylor J. Freeman, John Joseph Kelly, Samar Sayedyahossein, Brant E. Isakson, , Silvia Peñuela

bioRxiv · Sep 9, 2024 · PreprintCell Biology