Karen E. Pollok

This study shows ZNF423 depletion triggers the integrated stress response and sensitizes NF1-associated MPNST to chemotherapy, identifying it as a potential therapeutic target.

This paper identifies romidepsin as a promising repurposed drug for osteosarcoma using 3D spheroid models, showing efficacy against metastatic cells and outperforming other HDIs.

This study shows that inhibiting RPA gap protection enhances PARP inhibitor efficacy in BRCA1-deficient cancers by increasing genomic instability and reducing tumor growth.