Abigail L. Buchwalter

The paper identifies cardiomyocyte-specific vulnerabilities to LMNA mutations using saturation mutagenesis in hiPSCs and cardiomyocytes, revealing how lamin polymer disruption leads to disease.

This study shows that emerin loss impairs MyoD-driven differentiation of human iPSCs into skeletal myotubes by affecting PRC2-mediated gene regulation.

The paper identifies sequences affecting emerin's secretory trafficking, showing C-terminal tags and hydrophobic domains influence its lysosomal fate, while an ER retention motif stabilizes it.

The paper shows that the nuclear periphery represses H3K9me2-marked genes and transposons, and its loss disrupts cell fate transitions in mESCs.

The paper shows that LB1 and LAP2β resist cytoskeletal forces to maintain lamin A/C meshwork and nuclear integrity, preventing rupture upon their depletion.

This study investigates how O-GlcNAc modifications influence lamin A tail processing and identifies a potential link between glucose metabolism and lamina biogenesis.

This study models age-linked rDNA hypermethylation in human cells using dCas9-directed DNA methylation and finds no detectable effect on rRNA transcription or cellular growth.

TRAIL quantifies protein and cell lifetimes across tissues, showing cell division drives non-selective turnover in proliferative tissues while physicochemical features influence turnover in non-proliferative tissues.