Robert Hill

This study shows OPCs do not die during development, adulthood, remyelination, inflammation, or aging, indicating homeostasis does not rely on programmed cell death.

This study shows that CX3CL1/CX3CR1 signaling regulates microglia detection and phagocytosis of dying neurons in the mouse cortex.

The paper shows that injured mature oligodendrocytes lose mitochondria and survive without them for weeks to months before dying, unlike other oligodendrocyte lineage cells.

This study shows that TREM2 and APOE do not affect microglia phagocytosis of dying neurons in live mouse brains, but TREM2 influences microglia migration near amyloid plaques.

The paper shows that microglial processes involved in surveillance, chemotaxis, and phagocytosis lack mitochondria, while mitochondria arrive later in response to damage.

The paper identifies transient procaspase-3 upregulation in differentiating oligodendrocytes and shows its role in promoting differentiation and survival decisions.

The paper examines mitochondrial dynamics during oligodendrocyte generation in mouse and human cerebral cortex, finding transient expansion and depletion linked to cellular processes and aging.

The paper investigates how microglia remove dying oligodendrocytes, finding that CX3CR1 mediates cell engagement while MERTK is not required for clearance.

This study shows that oligodendrocyte maturation changes cell death mechanisms, with precursor cells dying quickly and mature cells dying slowly after genotoxic damage.

This study develops an inducible mouse model of neocortical heterotopia and identifies aberrant axonal pathfinding and hypermyelination associated with these ectopic neuronal clusters.

This study investigates age-related differences in remyelination by NG2-glia using a novel demyelination model and finds that remyelination efficiency declines with age due to failed oligodendrogenesis.

This paper introduces a fast, learning-free method for sparse segmentation and reconstruction of neural volumes, demonstrating high-quality results across multiple imaging modalities.