Yasmine Kamen

This study shows OPCs do not die during development, adulthood, remyelination, inflammation, or aging, indicating homeostasis does not rely on programmed cell death.

The paper shows that injured mature oligodendrocytes lose mitochondria and survive without them for weeks to months before dying, unlike other oligodendrocyte lineage cells.

This study shows that constitutive DREADD signalling in oligodendrocyte precursor cells alters bioelectrical properties and fate, highlighting a confound in using DREADDs in small cells.

The paper identifies transient procaspase-3 upregulation in differentiating oligodendrocytes and shows its role in promoting differentiation and survival decisions.

This study shows that oligodendrocyte maturation changes cell death mechanisms, with precursor cells dying quickly and mature cells dying slowly after genotoxic damage.