Post-weaning social isolation impairs the orbitofrontal cortical circuit subserving contagious pain and prosocial behaviors
Yu Gong, Su-Shan Guo, Xue Chen, Zichen Zhang, Xing-Lei Song, Qin Jiang, Ying Li, Dehua Wu, Tingting Zhang, Xuan Zhao, Fan Jiang, Hong Jiang, Ming‐Gang Liu, Tian-Le Xu
This study shows that post-weaning social isolation impairs empathic behaviors in mice by disrupting glutamatergic signaling in the orbitofrontal cortex.
bioRxiv · Dec 17, 2025 · PreprintNeuroscience