Re’em Moskovitz

This study characterizes the structure and function of antibodies targeting the conserved β-epitope region of PfCSP, showing how they achieve strain-transcending recognition and enhance Fc-mediated immune responses.

This study determines the structural basis of antigen recognition by two mAbs targeting PfCSP, revealing conserved and distinct binding modes and their implications for antibody function.

The paper determines the crystal structures of engineered monoclonal antibodies MAM01 and MS-1805 in complex with Plasmodium falciparum CSP, showing retained binding affinity and no significant conformational changes.