Frank Kozielski

The paper maps the fragment-binding landscape of SARS-CoV-2 nsp14, identifies promising sites for antiviral drug development, and provides a prioritized resource for future inhibitors.

This study examines the structural and functional effects of three KEAP1 mutants on NRF2 regulation using biophysical and structural methods, revealing their distinct impacts on protein stability and interaction.

This study determines the solution structure and dynamics of MERS-CoV nsp10, revealing intrinsic disorder and identifying potential ligands through NMR fragment screening.

The paper identifies a shared polymerisation switch mechanism in cytomotive actins and tubulins that ensures filament stability and functional dynamics.