Jan Löwe

This study shows that archaeal ESCRT-III homologue CdvB1 binds phosphoinositides and helps polarize the cytokinetic membrane in Sulfolobus acidocaldarius.

The paper identifies tubulins in Asgard archaea and shows they form mini-microtubules with eukaryotic-like properties, suggesting an archaeal origin for microtubules.

The paper presents structural studies of the archaeal CdvAB cell division machinery, showing CdvA forms helical filaments and CdvB adopts ESCRT-III-like folds, revealing membrane engagement mechanisms.

This paper introduces a foam film vitrification method for cryo-EM that improves ice thickness control and particle orientation, simplifying specimen preparation.

The paper investigates how the bacterial SMC complex MukBEF loads DNA and how a viral protein inhibits this process through DNA mimicry.

This paper presents the cryo-EM structure of the divisome core complex FtsWIQBL from Pseudomonas aeruginosa, revealing molecular mechanisms of divisome activation and a conformational switch between inactive and active states.

The paper identifies a shared polymerisation switch mechanism in cytomotive actins and tubulins that ensures filament stability and functional dynamics.

The paper presents cryo-EM structures of yeast condensin with DNA and ATP analogues, showing DNA clamping and neck gate closure during loop extrusion.

The paper presents the cryo-EM structure of the bacterial SMC complex MukBEF in complex with MatP and DNA, revealing how it entraps DNA loops at unloading sites.

This study determines the structure of favipiravir-RTP bound to SARS-CoV-2 RdRp, revealing its weak incorporation mechanism and low replication suppression.

The paper determines the cryo-EM structure of FtsK's motor domain translocating DNA, revealing a mechanism involving conformational changes and spiral staircase interactions.

The paper reports the high-resolution cryo-EM structure of Pseudomonas aeruginosa MinCD copolymeric filaments, revealing their composition and membrane interaction.

This study investigates the structural architecture of two SMC-kleisin complexes, revealing a folded conformation mediated by a dynamic coiled-coil discontinuity.

The paper investigates how Scc1 and Scc2 interactions regulate cohesin's ATPase activity and displacement of Pds5 during loading.

The paper shows MreB filaments align along principal membrane curvature to create rod shape in bacteria, supported by biophysical modeling and experimental observations.