Author

Kathryn M. Pflug

Texas A&M UniversityORCID 0000-0002-2472-0876Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Andrew Phillip WestiD· 1 shared Brian Robert HoffmanniD· 1 shared Camila Guerra MartineziD· 1 shared Carolyn L. CannoniD· 1 shared Jessica K. WongiD· 1 shared Jordyn J. VanPortflietiD· 1 shared Muthumeena RamanathaniD· 1 shared Peter J. McGuireiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Andrew Phillip WestORCID

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1 paper

Recent·Most cited

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease

Jordyn J. VanPortfliet, Yuanjiu Lei, Muthumeena Ramanathan, Camila Guerra Martinez, Jessica K. Wong, Timothy J. Stodola, Brian Robert Hoffmann, Kathryn M. Pflug, Raquel Sitcheran, Stephen C. Kneeland, Stephen A. Murray, Peter J. McGuire, Carolyn L. Cannon, Andrew Phillip West

This study identifies caspase-11 as a driver of macrophage hyperinflammation in Polg-related mitochondrial disease models, linking IFN-I signaling to exacerbated infection outcomes.

Nature Communications · May 20, 2025Peer-reviewedImmunology