Author

Lene Clausen

University of CopenhagenORCID 0000-0003-4556-9295Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:variant effect prediction· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Amelie SteiniD· 2 shared Kresten Lindorff‐LarseniD· 2 shared Martin Grønbæk-ThygeseniD· 2 shared Rasmus Hartmann‐PeterseniD· 2 shared Cecilie L. SøltoftiD· 1 shared Douglas M. FowleriD· 1 shared Kristoffer E. JohanssoniD· 1 shared Lasse NygaardiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Amelie SteinORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 2, 2023

Deep mutational scanning reveals a tight correlation between protein degradation and toxicity of thousands of non-native aspartoacylase protein variants

Martin Grønbæk-Thygesen, Vasileios Voutsinos, Kristoffer E. Johansson…·Rasmus Hartmann‐Petersen

The paper uses deep mutational scanning to show that protein degradation and toxicity are tightly correlated in ASPA variants linked to Canavans disease.

1 citation

humanproteomics

𝕏 PostBluesky

Molecular BiologyPLoS GeneticsPeer-reviewedNov 2, 2020

Folliculin variants linked to Birt-Hogg-Dube syndrome are targeted for proteasomal degradation

Lene Clausen, Amelie Stein, Martin Grønbæk-Thygesen…·Rasmus Hartmann‐Petersen

The paper shows that BHD-linked FLCN variants cause loss of function via proteasomal degradation and misfolding, with potential therapeutic implications for stabilization.

33 citations

humanproteomics

𝕏 PostBluesky