Elisa Zuccoli

This study shows that human midbrain organoids remain viable and show adaptive responses under microgravity and nutrient limitation on the ISS.

This study uses iPSC-derived neurons and midbrain organoids with SNCA triplication to show autophagy defects correlate with -Synuclein pathology and neuronal loss in Parkinson's disease.

This study shows that patient-derived microglia in midbrain organoids induce endogenous alpha-synuclein pathology without exogenous seeding.

This study evaluates the reproducibility of midbrain organoid data from healthy individuals and GBA-N370S PD patients across batches and time points, showing consistent transcriptomic and metabolic signatures.