Author

Isabel Rosety

OrganoTherapeutics SARL (Luxembourg)ORCID 0000-0001-9118-6995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:spatial transcriptomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Jens Christian SchwamborniD· 4 shared Gemma Gomez‐GiroiD· 3 shared Javier JarazoiD· 3 shared Alise ŽagareiD· 2 shared Elisa ZuccoliiD· 2 shared Sònia Sabaté‐SoleriD· 2 shared Aleksandar RakovićiD· 1 shared Ana Clara CristóvãoiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Jens Christian SchwambornORCID

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4 papers

Recent·Most cited

Neurosciencenpj Parkinson s DiseasePeer-reviewedMar 31, 2026

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a SNCA Triplication

Catarina Serra-Almeida, Javier Jarazo, Gemma Gomez‐Giro…·Jens Christian Schwamborn

This study uses iPSC-derived neurons and midbrain organoids with SNCA triplication to show autophagy defects correlate with -Synuclein pathology and neuronal loss in Parkinson's disease.

2 citationstop 3%

humanspatial transcriptomics

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NeurosciencebioRxivPreprintJul 1, 2025

Parkinsons disease microglia induce endogenous alpha-Synuclein pathology in patient-specific midbrain organoids.

Elisa Zuccoli, Henry Kurniawan, Isabel Rosety…·Jens Christian Schwamborn

This study shows that patient-derived microglia in midbrain organoids induce endogenous alpha-synuclein pathology without exogenous seeding.

DOI 10.1101/2025.07.01.662685

humanspatial transcriptomics

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NeurosciencebioRxivPreprintMar 28, 2025

Released mitochondrial DNA and neurofilament light chain as Parkinson's disease phenotypes in patient-specific midbrain assembloids

Sònia Sabaté‐Soler, Isabel Rosety, Gemma Gomez‐Giro…·Javier Jarazo

The paper assesses mitochondrial DNA and neurofilament light chain levels in midbrain assembloids to identify Parkinson's disease phenotypes and potential biomarkers.

1 citation

humanbulk RNA-seq

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NeurosciencebioRxivPreprintOct 22, 2019

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment

Javier Jarazo, Kyriaki Barmpa, Isabel Rosety…·Jens Christian Schwamborn

This study shows that HP-β-CD treatment improves dopaminergic differentiation in PD patient-derived midbrain organoids by enhancing mitophagy.

14 citations

humanexperimental assay

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