Juliet Bottorff

This study shows that cholinergic modulation is necessary for upward firing rate homeostasis in rodent visual cortex during active wake, but not during quiet wake.

The paper uses CaMPARI2 to label neurons based on firing rates and finds that high activity neurons in mouse V1 have increased intrinsic excitability and lower spike adaptation, contributing to higher firing rate set points.

The paper demonstrates that sleep enables downward firing rate homeostasis, which is distinct from upward homeostasis and occurs during sleep rather than wake.