Amanda J. Roberts

Astrocyte Reactivity by Alcohol Dependence in the Central Amygdala

This study identifies astrocyte reactivity in the central amygdala due to ethanol dependence through multi-omics analysis in mice, revealing adaptive and maladaptive changes in neuroimmune and cytoskeletal pathways.

Redox regulation of neuroinflammatory pathways contributes to damage in Alzheimers disease brain

The paper identifies S-nitrosylation of STING as a redox modification driving aberrant cGAS-STING signaling in Alzheimer's disease, contributing to neuroinflammation and synaptic loss.

The effects of Alcohol Dependence on the CSF Proteome in Mice: Evidence for Blood-Brain Barrier Dysfunction and Neuroinflammation

This study uses proteomics to compare CSF from alcohol-dependent and non-dependent mice, identifying molecular changes linked to BBB dysfunction and neuroinflammation.

Alcohol Dependence-Induced Astrocyte Immune Activation in the Nucleus Accumbens

This study identifies astrocyte-specific gene and pathway changes in the nucleus accumbens during alcohol dependence using RNA-Seq and TRAP, revealing distinct immune activation patterns compared to ethanol drinking.

Sex specific disruptions in Protein Kinase Cγ signaling in a mouse model of Spinocerebellar Ataxia Type 14

The paper develops a mouse model of SCA14 with a clinically relevant PKCγ mutation, identifies sex-specific disease mechanisms, and highlights potential therapeutic targets for males.

Ethanol's interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice

This study investigates whether ethanol's interaction with BK channel α subunit residue K361 mediates behavioral responses to alcohol in mice, finding no significant effects on ethanol-related behaviors or consumption.

ImAge: an imaging approach to quantitate aging and rejuvenation.

The paper introduces ImAge, an image-based biomarker of aging and rejuvenation using chromatin and epigenetic patterns, showing correlation with chronological age and response to interventions.

Reelin deficiency exacerbates cocaine-induced hyperlocomotion by enhancing neuronal activity in the dorsomedial striatum.

This study shows that Reelin deficiency increases cocaine-induced hyperlocomotion in mice by enhancing neuronal activity in the dorsomedial striatum, without affecting cocaine reward.

The impact of phosphorylated Pten at threonine 366 on cortical connectivity and behaviour

This study investigates the role of Pten T366 phosphorylation in cortical connectivity and behavior, finding that its disruption leads to cognitive deficits and sensory impairments in mice.

Haploinsufficiency of autism candidate gene NUAK1 impairs cortical development and behavior

This study shows that haploinsufficiency of the autism candidate gene Nuak1 in mice causes cortical development defects and behavioral abnormalities resembling ASD, intellectual disability, and schizophrenia.