Author

Brendan Antiochos

Johns Hopkins UniversityORCID 0000-0001-6166-9750Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Jungsan SohniD· 2 shared Shuai Wu· 2 shared Stephanie Torres· 2 shared Alexander Strom· 1 shared Christina M StallingsiD· 1 shared Hannah Wendorff· 1 shared Jacob Lueck· 1 shared Jasper MohiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

Jungsan SohnORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintMay 21, 2026

Protein-DNA mesh assembly drives dsDNA-specific and duplex length-dependent activation of cGAS

Shuai Wu, Christina M Stallings, Stephanie Torres…·Jungsan Sohn

This study shows cGAS forms a protein-dsDNA mesh that enables dsDNA-specific and length-dependent activation through higher-order assembly.

DOI 10.64898/2026.05.19.726263

cryo-EMproteomics

𝕏 PostBluesky

BiochemistryCell ReportsPeer-reviewedJan 23, 2026

Dimerization-dependent gel-like condensation with dsDNA underpins the activation of human cGAS

Jacob Lueck, Alexander Strom, Stephanie Torres…·Jungsan Sohn

This study shows that cGAS dimerization on dsDNA forms gel-like condensates, which activate cGAS and protect dsDNA, while single-stranded RNA can dissolve these condensates.

5 citationstop 2%

humanDNA methylation

𝕏 PostBluesky