Author

Shuai Wu

Johns Hopkins UniversityPrimary ORCID profile (0000-0003-1818-0831 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Shuai WuiD2 papers · Key Laboratory of Guangdong Province

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Assay:proteomics· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Jungsan SohniD· 3 shared Stephanie Torres· 3 shared Brendan AntiochosiD· 2 shared Alexander Strom· 1 shared Christina M StallingsiD· 1 shared Gerald S. ShadeliD· 1 shared Gregory D. BowmaniD· 1 shared Guannan Huang· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

Jungsan SohnORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

cGAS bends unpaired DNA to form an unconventional structure that hyperactivates the innate immune response

Shuangshuang Yang, Shuai Wu, Silian Chen, Xin Li, Iryna Chelepis, Smaranda Willcox, Katherine Camille Barnett, Xiaoqing Hu, Guannan Huang, W. June Brickey, Joseph A. Duncan, Wei-Chun Chou, Pengda Liu, William G. Fusco, Stephanie Torres, , Jenny P.‐Y. Ting

The paper shows that cGAS hyperactivates in response to unpaired DNA (Bu-DNA) by bending it into a V-shape, revealing a new activation mechanism.

bioRxiv · May 25, 2026 · PreprintImmunology

Protein-DNA mesh assembly drives dsDNA-specific and duplex length-dependent activation of cGAS

Shuai Wu, Christina M Stallings, Stephanie Torres, Brendan Antiochos, Jungsan Sohn

This study shows cGAS forms a protein-dsDNA mesh that enables dsDNA-specific and length-dependent activation through higher-order assembly.

bioRxiv · May 21, 2026 · PreprintBiophysics

Dimerization-dependent gel-like condensation with dsDNA underpins the activation of human cGAS

Jacob Lueck, Alexander Strom, Stephanie Torres, Shuai Wu, Jasper Moh, Hannah Wendorff, Brendan Antiochos, Jungsan Sohn

This study shows that cGAS dimerization on dsDNA forms gel-like condensates, which activate cGAS and protect dsDNA, while single-stranded RNA can dissolve these condensates.

Cell Reports · Jan 23, 2026Peer-reviewedBiochemistry