John Peregrin

This study shows FGF signaling is essential for mammalian retinal regeneration by enabling Muller glia to overcome transcriptional barriers through sustained ERK activation.

The paper identifies mitochondrial dysfunction in a glaucoma model using single-cell analysis and shows that vitamin B3 treatment protects against IOP elevation.

The paper uses single-cell transcriptomics to characterize anterior segment development, identifying cell types, pathways, and signaling networks in trabecular meshwork and Schlemm's canal formation.

This study identifies Shc1 as a critical collaborator with Frs2 and Shp2 in recruiting Grb2 during FGF signaling for lens development.

The paper performs transcriptomic analyses of Schlemm's canal endothelial cells to reveal their lymphatic identity, three major cell states, and interactions with trabecular meshwork cells.

The paper investigates how CyclinD2 regulates RGC neurogenesis in the mouse ciliary margin zone and shows its disruption in albinism leads to impaired binocular vision.

The paper shows that FGF and Wnt signaling gradients determine phase transitions in vertebrate eye cup development, specifying cell fates through their combinatorial code.