Yingyu Mao

The paper shows that Wnt signaling, through {beta}-catenin, regulates passive cell competition in the retina by inducing a cadherin switch that segregates cells into distinct compartments.

This study identifies Shc1 as a critical collaborator with Frs2 and Shp2 in recruiting Grb2 during FGF signaling for lens development.

This study identifies an mTOR-Wnt-Rac1 signaling axis that regulates cytoskeletal tension to drive lens vesicle closure, with disruptions leading to developmental defects like Peters anomaly.

This study optimizes a PROTAC to degrade IDO1 with high potency in GBM cells, showing sustained degradation via the ubiquitin-proteasome system.

This study identifies Abl kinases as regulators of FGF signaling that prevent Peters anomaly by modulating RhoA and Rac1 activity through the Ptpn12-p130Cas pathway.

The paper shows that FGF and Wnt signaling gradients determine phase transitions in vertebrate eye cup development, specifying cell fates through their combinatorial code.