Daniele Bertoglio

This paper develops a harmonized MRI QC framework using phantoms to identify sources of variability across field strengths and sites, showing that field strength alone does not fully characterize MRI performance.

This study uses longitudinal MRI to analyze brain volume changes in zQ175DN mice, finding early striatal atrophy and later cortical and corpus callosum reductions similar to human HD.

This study evaluates long-term dietary interventions in a rat model of Alzheimer's disease, finding limited effects on functional connectivity and cognitive decline.

This study evaluates [11C]CHDI-009R as a PET radioligand for quantifying mutant huntingtin aggregates in a mouse model of HD, showing high stability, reliability, and genotype differentiation.

The paper characterizes early CLN7 disease in macaques using multimodal biomarkers, revealing region-specific brain changes and neurodegeneration markers.

This study examines longitudinal changes in structural and effective connectivity in a non-human primate HD model, finding reduced structural connectivity and early effective connectivity changes.

This study compares the effects of caloric restriction and resveratrol on brain network connectivity in male and female rats, finding sex-specific changes in functional connectivity.

The paper validates [18F]UCB-J as a selective SV2A PET ligand in mice, showing reliable kinetics and volume of distribution measurements.

This paper evaluates [18F]CHDI-650, a novel PET radiotracer, for imaging mutant huntingtin aggregates in HD mouse models, showing genotype discrimination at 3 and 9 months.

This paper applies ICA to SV2A PET data in mice to identify pre-synaptic density networks, showing age-related changes and disease impacts in HD models.

This paper develops a PET radioligand to visualize mutant huntingtin levels in the brain and assess therapeutic interventions in Huntington's disease.