Daniel M. DuBreuil

The paper introduces APPOINT, a platform for high-throughput physiological profiling of individual neurons, identifying subtypes and mechanisms of activation and drug responses.

The paper develops a cultured sensorimotor organoid model that forms functional neuromuscular junctions and uses it to study ALS subgroups.

This study shows that peripheral CaV2.2 channels in skin are essential for thermal hyperalgesia but not mechanical hypersensitivity after capsaicin exposure in mice.