Diane Lipscombe

This paper introduces a modular platform called Interluminescence that uses bioluminescent light to control synaptic transmission by activating optogenetic ion channels in postsynaptic neurons.

The paper introduces BLADe, a platform that converts intracellular activity into photoreceptor activation using bioluminescent sensors and actuators, demonstrating its use in neurons for activity-dependent gene expression and neural dynamics control.

This paper introduces CaBLAM, a bioluminescent Ca2+ indicator with improved dynamic range and Ca2+ affinity, enabling high-resolution imaging of cellular activity in cultured neurons and in vivo.

The paper investigates the cell-specific role of CaV2.2 channels in Trpv1-lineage neurons using Cacna1b gene inactivation and shows their involvement in heat hypersensitivity.

This study shows that peripheral CaV2.2 channels in skin are critical for heat hypersensitivity during chronic neuroinflammation but not for mechanical hypersensitivity or edema.

This study identifies interleukin-1 as the key cytokine mediating rapid adaptive increases in heat and mechanical sensitivity in skin following capsaicin exposure.

This study evaluates factors affecting luminopsin efficacy and identifies strategies to improve their function through molecular evolution.

This study examines how two ω-phonetoxins inhibit different splice variants of CaV2.2 channels in dorsal root ganglia, contributing to understanding their analgesic effects.

The paper introduces a new bioluminescent optogenetic molecule (LMO7) that enhances chemogenetic activation efficacy compared to existing variants, showing improved neuronal activity modulation and behavioral control.

This study shows that Sod1G85R knock-in mice exhibit up-regulated cholesterol synthesis pathways and limited neurodegeneration, contrasting with severe TgSOD1G93A mice, suggesting lipid pathway dysregulation in ALS.

The paper introduces a method to control synaptically connected neurons using bioluminescent light, validated in cultured neurons and mice.

This study shows that peripheral CaV2.2 channels in skin are essential for thermal hyperalgesia but not mechanical hypersensitivity after capsaicin exposure in mice.

The paper identifies cell-specific exon methylation and CTCF binding as regulators of calcium channel splicing in neurons, showing how these mechanisms are disrupted in nerve injury and chronic pain.

The paper identifies sensory feedback defects as an early event in ALS motor dysfunction in a Drosophila model and shows BMP signaling in proprioceptors can alleviate motor deficits.