Eduardo Javier López Soto

The paper shows that an alternative splicing variant of CAPS1 in nociceptors enhances CaV2.2 channel activity, contributing to inflammatory pain hypersensitivity.

This study shows that peripheral CaV2.2 channels in skin are essential for thermal hyperalgesia but not mechanical hypersensitivity after capsaicin exposure in mice.

The paper identifies cell-specific exon methylation and CTCF binding as regulators of calcium channel splicing in neurons, showing how these mechanisms are disrupted in nerve injury and chronic pain.