Prakash Arumugam

This study shows that disrupting GPI-anchor biosynthesis in fungi changes cell wall composition and morphology, leading to dispersed growth and altered adhesion.

This study uses CRISPR/Cas9 screening to identify lipid metabolism and inflammatory signaling genes that modulate GA-DM cytotoxicity in melanoma cells.

This study enhances γ-decalactone production in S. cerevisiae by identifying Faa2 as critical for oleic acid-to-γ-decalactone conversion.

This study identifies three distinct pathways by which glucose metabolism activates TORC1 in yeast, including both Rag GTPase-dependent and independent mechanisms.

This study shows TORC1 activates in response to glucose and regulates gene expression via the Tap42-Sit4-Rrd1/Rrd2 pathway, controlling yeast growth and development.

This study identifies 33 genes modulating vemurafenib resistance in melanoma cells using a CRISPR/Cas9 screen, with 14 genes previously unreported.