Shawn S. Hoon

This study enhances γ-decalactone production in S. cerevisiae by identifying Faa2 as critical for oleic acid-to-γ-decalactone conversion.

This paper identifies evolutionarily conserved LRR proteins in velvet worm slime that form receptor-like structures, enabling reversible supramolecular network formation in bioadhesive fibers.

This study shows that PAX4 variants reduce beta cell function and increase diabetes risk by impairing insulin secretion and hormone gene expression in human cells.

MapCell uses Siamese neural networks to learn a cell type distance metric, enabling annotation transfer across scRNA-seq datasets and identifying novel cell types.

This study shows TORC1 activates in response to glucose and regulates gene expression via the Tap42-Sit4-Rrd1/Rrd2 pathway, controlling yeast growth and development.

The paper evaluates alternative CRISPR-Cas systems for genome editing in streptomycetes, showing that sth1Cas9, saCas9, and fnCpf1 enable efficient genomic modifications where SpCas9 fails.