A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity
Adinda Kok, Samuel H. Wilks, Sina Türeli, Sarah L. James, Theo M. Bestebroer, David F. Burke, Mathis Funk, Stefan van der Vliet, Monique I. J. Spronken, Willemijn F. Rijnink, David J. Pattinson, Dennis de Meulder, Miruna E. Rosu, Pascal Lexmond, Judith M. A. van den Brand, , Mathilde Richard
The paper creates a high-resolution antigenic map of A(H5) HA and uses it to design vaccine antigens that confer broad immunity against diverse A(H5) viruses.
Nature · Oct 15, 2025Peer-reviewedMicrobiology