The study analyzes MERS-CoV genetic diversity in Saudi Arabian dromedary camels and humans, identifying new variants with unique Spike protein polymorphisms.

Emerging infectious diseases · Dec 11, 2024Peer-reviewedEvolutionary Biology

Comparative Analysis of SARS-CoV-2 Antigenicity across Assays and in Human and Animal Model Sera

Barbara Mühlemann, Samuel Wilks, Lauren Baracco, Meriem Bekliz, Juan Manuel Carreño, Victor M. Corman, Meredith E. Davis-Gardner, Wanwisa Dejnirattisai, Michael Diamond, Daniel C. Douek, Christian Drosten, Isabella Eckerle, Venkata Viswanadh Edara, Madison Leigh Ellis, Ron A. M. Fouchier, , Derek J. Smith

The paper compares SARS-CoV-2 antigenicity across assays and in human and animal model sera, finding similar immunodominance patterns and antigenic maps but differences in titer magnitude and assay-specific fold change.

bioRxiv · Sep 27, 2023 · PreprintBioinformatics

Genetic variability, including gene duplication and deletion, in early sequences from the 2022 European monkeypox outbreak

Terry C. Jones, Julia A. Schneider, Barbara Mühlemann, Talitha Veith, Jörn Beheim-Schwarzbach, Julia Tesch, Marie Luisa Schmidt, Felix Walper, Tobias Bleicker, Caroline Isner, Frieder Pfäfflin, Ricardo Niklas Werner, Victor M. Corman, Christian Drosten

The paper analyzes genome sequences from the 2022 European monkeypox outbreak to identify genetic variability, including gene duplication and deletion, and their potential role in viral adaptation.

bioRxiv · Jul 23, 2022 · PreprintBioinformatics

HLA-C* 04:01 is a Genetic Risk Allele for Severe Course of COVID-19

Weiner January, Phillip Suwalski, Manuel Holtgrewe, Charlotte Thibeault, Melina Müller, Dimitri Patriki, Claudia Quedenau, Ulrike Krüger, Tania Elisa, Lena Johanna Lippert, Stubbemann Paula, Real Luis Miguel, Sanchez Juan Macias, A. Pineda Juan, Marta Fernández‐Fuertes, , Bettina Heidecker

The paper identifies HLA-C* 04:01 as a genetic risk allele associated with increased intubation risk in severe COVID-19 cases, validated across multiple cohorts.

medRxiv · Dec 21, 2020 · PreprintGenetic & Genomic Medicine

Whole-Genome Sequences of the Severe Acute Respiratory Syndrome Coronavirus-2 obtained from Romanian patients between March and June of 2020

Mihaela Lazăr, Odette Popovici, Barbara Mühlemann, Tim Durfee, Razvan Costin Stan

The paper reports whole-genome sequences of SARS-CoV-2 from Romanian patients and analyzes mutations in the Spike glycoprotein's impact on protein stability and infectivity.

bioRxiv · Jun 28, 2020 · PreprintBioinformatics