Tongbin Wu

The paper shows that cardiac defects in ATF4 knockout mice result from unintended Rps19bp1 downregulation due to transcriptional readthrough, not loss of ATF4 function.

This study identifies MYRF's critical role in epicardial development and links its deficiency to cardiac abnormalities in CUGS.

This study shows RBPMS and RBPMS2 work together to regulate cardiac splicing, with double knockout mice dying in utero due to sarcomere disarray, while single knockouts survive with normal sarcomere structure.