Author

Xiaohai Zhou

University of California San DiegoORCID 0000-0002-0987-0374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ju CheniD· 2 shared Tongbin WuiD· 2 shared Yusu GuiD· 2 shared Zengming Zhang· 2 shared Zeyu CheniD· 2 shared Chao GaoiD· 1 shared Christopher M. AdamsiD· 1 shared Danni CheniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetics

Ju ChenORCID

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2 papers

Recent·Most cited

GeneticsCardiovascular ResearchPeer-reviewedNov 14, 2025

Transcriptional Readthrough at Atf4 Locus Suppresses Rps19bp1 and Impairs Heart Development

Zengming Zhang, Tongbin Wu, Zeyu Chen…·Ju Chen

The paper shows that cardiac defects in ATF4 knockout mice result from unintended Rps19bp1 downregulation due to transcriptional readthrough, not loss of ATF4 function.

5 citations

mouseexperimental assay

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Developmental BiologyCirculation ResearchPeer-reviewedAug 27, 2025

RBPMS and RBPMS2 Cooperate to Safeguard Cardiac Splicing

Tongbin Wu, Zeyu Chen, Chao Gao…·Ju Chen

This study shows RBPMS and RBPMS2 work together to regulate cardiac splicing, with double knockout mice dying in utero due to sarcomere disarray, while single knockouts survive with normal sarcomere structure.

3 citations

mousebulk RNA-seq

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