Author

Domenico Garozzo

Institute of Polymers, Composites and BiomaterialsORCID 0000-0002-9087-9818Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alexey V. PshezhetskyiD· 2 shared Luisa SturialeiD· 2 shared Shunji TomatsuiD· 2 shared Afitz Da SilvaiD· 1 shared Akhilesh PandeyiD· 1 shared Alexei GorelikiD· 1 shared Angela MessinaiD· 1 shared Angelo PalmigianoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Alexey V. PshezhetskyORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mice with mono-allelic p.R37H Dhdds variant show aberrant glycosylation and interneuron deficits

Afitz Da Silva, Merrick S. Fallah, Samuel Boris Tene Tadoum, Mehrnaz Fazeli, Irena Josephina Johanna Muffels, Siyan Wang, François Grenier, Rohit Budhraja, Luisa Sturiale, Angela Messina, Moshe Giladi, Mahsa Taherzadeh, Éric Bonneil, Shaukat Khan, Daniëlle te Vruchte, , Alexey V. Pshezhetsky

This study describes a mouse model of DHDDS-CDG, showing seizures, myoclonus, and cognitive deficits linked to glycosylation defects and interneuron abnormalities.

Brain · Sep 11, 2026Peer-reviewedNeuroscience

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

TianMeng Xu, Rachel Heon‐Roberts, Travis Moore, Patricia Dubot, Xuefang Pan, Tianlin Guo, Christopher W. Cairo, Rebecca J. Holley, Brian Bigger, Thomas M. Durcan, Thierry Levade, Jérôme Ausseil, Bénédicte Amilhon, Alexei Gorelik, Bhushan Nagar, , Alexey V. Pshezhetsky

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

Journal of Clinical Investigation · Jun 17, 2025Peer-reviewedBiochemistry