Author

Joshua G. Pemberton

National Institutes of HealthORCID 0000-0002-1492-1471Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Claire C. WeckerlyiD· 2 shared Gerald R. V. HammondiD· 2 shared Tamás BallaiD· 2 shared Alejandro Álvarez-PratsiD· 1 shared Alexandria L ShawiD· 1 shared Calvin K. YipiD· 1 shared John E. BurkeiD· 1 shared John E. HeuseriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

Claire C. WeckerlyORCID

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4 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedSep 7, 2026

Endogenous tracking reveals paralog-specific targets for phosphatidic acid generation during phospholipase C signaling in living cells

Claire C. Weckerly, Olivia L. Murtagh, Tiernan Swayhoover…·Gerald R. V. Hammond

The paper investigates paralog-specific effects of DGK inhibitors on PA generation during PLC signaling in live cells, finding that BMS-502 inhibits PA production while R59022 paradoxically increases it.

DOI 10.1016/j.jbc.2026.113520

humanproteomics

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Cell BiologyThe Journal of Cell BiologyPeer-reviewedAug 8, 2025

PILS-Nir1 is a novel phosphatidic acid biosensor that reveals mechanisms of lipid production

Claire C. Weckerly, Taylor A. Rahn, Max Ehrlich…·Gerald R. V. Hammond

The paper develops PILS-Nir1, a phosphatidic acid biosensor, and shows it detects PA dynamics in live cells with higher sensitivity than existing tools.

14 citationstop 4%

humanfluorescence / live-cell microscopy

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BiochemistryScience AdvancesPeer-reviewedDec 20, 2024

Molecular basis for plasma membrane recruitment of PI4KA by EFR3

Sushant Suresh, Alexandria L Shaw, Joshua G. Pemberton…·John E. Burke

The paper reports a cryo-EM structure of EFR3A bound to the PI4KA complex, revealing the molecular mechanism of PI4KA membrane recruitment and its regulation in human disease.

20 citations

humanstructural biology

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Cell BiologybioRxivPreprintMar 7, 2024

Defining the EM-signature of successful cell-transfection

Joshua G. Pemberton, Tatyana I. Tenkova, Philip Louis Felgner…·John E. Heuser

The paper uses electron microscopy to identify unique structural changes in cells after transfection with Lipofectamine 2000 and 3000, providing a method to distinguish successfully transfected cells.

3 citations

imagingexperimental assay

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