Author

Meredith L. Jenkins

University of VictoriaORCID 0000-0002-0685-5048Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

John E. BurkeiD· 4 shared Alexandria L ShawiD· 3 shared Calvin K. YipiD· 3 shared Matthew AH ParsoniD· 3 shared Sushant SureshiD· 3 shared Noah J HarrisiD· 2 shared Aidan AnastasiD· 1 shared Alejandro Álvarez-PratsiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiochemistry

John E. BurkeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Phosphorylation of the C-terminus of PI4KA inhibits lipid kinase activity

Alexandria L Shaw, Sophia Doerr, Hunter G. Nyvall, Meredith L. Jenkins, Sushant Suresh, Calvin K. Yip, Scott D. Hansen, John E. Burke

This study identifies phosphorylation of Y2090 in PI4KA as an inhibitory mechanism that suppresses its lipid kinase activity through conformational changes and reduced membrane recruitment.

bioRxiv · Sep 10, 2026 · PreprintBiochemistry

Mapping SARS-CoV-2 Nucleocapsid Function with Nanobodies

Jules B. Weinstein, Timothy A. Bates, Aidan Anastas, Ayna Alfahdli, Mila Trank-Greene, Savannah K. McBride, Michelle Garcia, Matthew AH Parson, Meredith L. Jenkins, John E. Burke, Eric Barklis, Fikadu Tafesse

This study develops domain-specific nanobodies that inhibit SARS-CoV-2 infection by disrupting N protein phase separation and replication.

bioRxiv · Jan 27, 2026 · PreprintMicrobiology

Molecular basis for plasma membrane recruitment of PI4KA by EFR3

Sushant Suresh, Alexandria L Shaw, Joshua G. Pemberton, Mackenzie K. Scott, Noah J Harris, Matthew AH Parson, Meredith L. Jenkins, Pooja Rohilla, Alejandro Álvarez-Prats, Tamás Balla, Calvin K. Yip, John E. Burke

The paper reports a cryo-EM structure of EFR3A bound to the PI4KA complex, revealing the molecular mechanism of PI4KA membrane recruitment and its regulation in human disease.

Science Advances · Dec 20, 2024Peer-reviewedBiochemistry

Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A

Alexandria L Shaw, Sushant Suresh, Matthew AH Parson, Noah J Harris, Meredith L. Jenkins, Calvin K. Yip, John E. Burke

The paper reports a cryo-EM structure of Calcineurin bound to PI4KA, revealing direct interactions with both PI4KA and FAM126A and their conserved binding sequences.

Structure · Aug 30, 2024Peer-reviewedBiochemistry