Hanzhang Lu

The paper identifies microbleeds as a specific marker of amyloid-related vascular injury in 5xFAD mice, distinct from small-vessel disease.

This study introduces a bidirectional crusher gradient method to estimate labeling efficiency in pCASL MRI for mice, finding typical efficiencies of 0.780 +/- 0.048.

The paper identifies cell type-specific transcriptomic changes in 5XFAD mice that link BBB dysfunction and metabolic dysregulation to early AD pathogenesis.

This study shows that senolytic therapy with D+Q preserves BBB integrity and improves cognitive function in a tauopathy mouse model.

This study uses MRI and fluorescence imaging to show impaired glymphatic function in a mouse model of Huntington disease, suggesting it as a potential biomarker and therapeutic target.

This study introduces a new MRI technique to simultaneously measure perfusion parameters of small blood and lymphatic vessels in the human brain, showing faster signal changes in blood vessels than lymphatic ones.

This study shows that HTT silencing in premanifest HD mice delays disease onset and slows progression, using CBVa as a noninvasive biomarker.

This study analyzes how cerebrovascular reactivity affects static and dynamic functional network connectivity using fMRI, finding weaker connectivity during vasodilation and incomplete recovery after CO2 inhalation.